gproteincoupled
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Signal transduction, adenylyl cyclase coupled to a G alpha protein Royalty Free Stock Photo
A zoomedin view of a Gprotein coupled receptor with its binding site exposed and waiting for a ligand to initiate Royalty Free Stock Photo
   
   
   
   
   
G proteins mediate cell signaling
   
   
   
   
   
   
   
After dopamine binding, the dopamine receptor changes his shape and binds the inactive G protein.The G protein expels its GDP molecule replacing it by GTP. and falls into two pieces. The Galpha subunit binds to and activates the enzyme adenylyl cyclase, which produces then cyclic AMP spreading a signal through the cell. Source: PDB entries 7ljd, 6r3q

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